The challenge of embryonic mosaicism in preimplantation genetic screening
نویسندگان
چکیده
منابع مشابه
Preimplantation Genetic Screening
In the last 30 years, genetic testing techniques have been developed to identify chromosomally normal embryos in vitro, thereby potentially increasing the proportion of successful cycles with elective single-embryo transfer, and minimizing twin-pregnancy complications and miscarriages. This testing is termed "pre-implantation genetic screening" (PGS), in contrast to preimplantation genetic diag...
متن کاملAccuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos
BACKGROUND To preclude transfer of aneuploid embryos, current preimplantation genetic screening (PGS) usually involves one trophectoderm biopsy at blastocyst stage, assumed to represent embryo ploidy. Whether one such biopsy can correctly assess embryo ploidy has recently, however, been questioned. METHODS This descriptive study investigated accuracy of PGS in two ways. Part I: Two infertile ...
متن کاملI-20: Towards The Transparent Embryo: Dynamics and Ethics of Comprehensive Preimplantation Genetic Screening
Background: To study the ethical aspects of comprehensive preimplantation genetic screening (PGS) through microarrays and whole genome sequencing Materials and Methods: In order to pinpoint ethical issues regarding comprehensive embryo screening we have first investigated the technical and moral issues by organizing a campus meeting with experts and by a literature study. Subsequently we have i...
متن کاملIn vitro fertilization with preimplantation genetic screening.
BACKGROUND Pregnancy rates in women of advanced maternal age undergoing in vitro fertilization (IVF) are disappointingly low. It has been suggested that the use of preimplantation genetic screening of cleavage-stage embryos for aneuploidies may improve the effectiveness of IVF in these women. METHODS We conducted a multicenter, randomized, double-blind, controlled trial comparing three cycles...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2016
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2016.01.007